Effects of Nicotine
Effects of Nicotine
Last activity on January 3, 2025
Nicotine Addiction
- Nicotine binds to nicotinic receptor stimulating dopamine release.
- This results in the satisfaction associated with smoking.
- A drop in nicotine levels leads to craving and withdrawal.
Nicotine binds predominantly to nicotinic acetylcholine (nACh) receptors in the CNS; the primary is the α4β2 nicotinic receptor in the Ventral Tegmental Area (VTA)
After nicotine binds to the α4β2 nicotinic receptor in the VTA, it results in a release of dopamine in the Nucleus Accumbuns (nAcc) which is linked to reward
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